Orthopedics study guide

Apr 16th, 2015
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CALCIUM ANDPHOSPHATEMETABOLISMDR LUTOMIA MLFCS (ORTHO)CALCIUMIMPORTANT IN NERVE AND MUSCLE FUNCTIONCLOTTING ETC99% IN BONEPLASMA HAS <1%-HALF FREE, HALF BOUNDBINDING TO ALBUMINABSORPTION- DUODENUM-ACTIVETRANSPORT, AND JEJUNUM-PASSIVE DIFFISIONCALCIUMATP AND CA Binding PROTEIN REQUIRED FORABSORPTIONABSORPTION REGULATED BY 1,25(OH)DIHYDRO VITAMIN D398%REABSORBED BY KIDNEY-60% INPROXIMAL TUBULECA CAN BE EXCRETED IN STOOL,BUT USUALLYIN THE KIDNEYSRDA 600MG CHILDRENRDA 1300 ADOLESCENTS AND YOUNG ADULTS10-25YRSCALCIUM25-65 YRS MEN/WOMEN-750MG DAILYPREGNANT WOMEN-1500MG DAILYLACTATING WOMEN-2000MG DAILYPOSTMENOPAUSAL WOMEN AND FRACTUREDLONG BONE-1500MG DAILYAGE 0-30YRS-POSITIVE CALCIUM BALANCE>40YRS-NEGATIVE BALANCEABOUT 400MG CA IS RELEASED FROM BONEDAILYHORMONESPTH PEPTIDE-84 AA-CHIEF CELLS OFPARATHYROID-SECRETED IN RESPONSE TO LOW CA-SECRETION INHIBITED BY HIGH CA,ANDHIGH VIT D3-EFFECTS-GUT-NO DIRECT FXKIDNEY-STIMULATES MITOCHONDRIAOF PROX TUBULES TO CONVERT 25OHTO 1,25 DIHYDRO D3INCREASED REABSORPTION OF CACTDKIDNEY- INCREASED URINARY PO4 EXCRETIONBONE-INCREASED OSTEOCLASTICRESORPTION, AND NEW OSTEOCLASTRECRUITMENTNET FX-INCREASED SERUM CA, REDUCEDSERUM PO4MAY PLAY ROLE IN BONE LOSS IN EDERLYPTH RELATED PROTEIN AND RECEPTOR AREIMPLICATED IN METAPHYSIAL DYSPLASIAVITD3-STEROIDFROM PROX TUBULE KIDNEY25HYDROXYLATION-LIVER, 1-KIDNEY

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