orthopedics notes

Apr 16th, 2015
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METABOLIC BONEDISEASESPagets and othersOsteopetrosisMarble boneAlbers Schonberg diseaseHeterogenous and heritableosteopetrosisIncreased bone densityShort bonesAbnormal metaphyseal flaring (Erlenmeyerflask deformeity)No medula- anaemia, extramedullaryhematopoiesisDisturbed bone microarchitecture- fracturesNarrow cranial foraminae- increased ICP, opticatrophy deafnessDeath from anemia, bleeding or infectionearly ageSome milder forms (AR) may live to adulthoodand must be differentiated from metastasesand myelosclerosis.? abnormal osteoclast activityOsteoclasts have defective carbonicanhydrase, or defective hydrogen ATPaseproton pump or defective chloride channelTransplantation of normal bone marrow cellsor spleen cells may hold promise to rxOPG- osteoclastogenetic read about itPagetss disease-1876The case that he described :a military gentlemanwho had been his patient for more than 20 yearsthe patient was first seen, because of deformityin the left tibia.The left femur and tibia became larger, heavier,and more curved. the bones of the right limbfollowed thesame course. The skull became larger so thatnearly everyyear his hat needed to be enlarged. The attitudein standing was described as looking simian,the patients sight was partially destroyed byretinal hemorrhages, first in one eye and then inthe other, and nearly the same t

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