chemistry illustrated

Apr 16th, 2015
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THE EPIDEMOLOGYOF EPILEPSY[With special reference to Kenya]Dr T KwasaNeurophysicianHISTORY OF EPILEPSYHas been known since pre-historic times.Ancient Greeks-Holy sickness.Hippocrates 450BC-Originates from brain.The Bible- Evil Sprits- Demons- Conversion of Saul to PaulEpilepsy Definitions:1.Seizures2.Epilepsy3.Active Epilepsy4.Status EpilepticusPathogenesis Seizures result from excitation/inhibitionimbalance Arise from grey matter only Increased excitation=start abnormaldischarge Reduced Inhibition=allows spreadPathogenesis ContdHypersynchrony of action potentialsSustained neuronal depolarisationSufficient activation to recruit neighboursLoss of surround inhibitionHISTORYGalenCONTD- Build up of phlegm.Others- Moon sickness- Ivasion by external Toxin or poison.-Mordern views - Similar to those ofHippocratesHistorical figures believed tohave had EpilepsyJulius CaesarGautama BuddhaNapoleon BonapurtePeter TchaikorskyAlexandar the GreatAlfred NobelSt. PaulINCIDENCE 11-134/100,000/year-WHO-Laidlow et al 1993-shorvn 1990-shorvon &Farmer 1988 Average50/100,000/year1st Peak-2ndPeak-1st year of life8th Decade-Industrialized-Dekkar 1994-Shorvon 1990worldPREVALENCEWorld range 1.5-49/1000.Overall world Prevelance-4/1000Higher in Blacks than in Whites

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