hiv clinical staging

Apr 16th, 2015
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WHO AND CLINICAL STAGING OFHIV/AIDSDR JOHN KINUTHIAUNIVERSITY OFNAIROBI/KNHHUMAN IMMUNODEFICIENCY VIRUS (HIV)exists in two forms:HIV 1 which is the commonest cause ofinfections world wide and HIV 2 which is foundprimarily in West Africa, Mozambique and AngolaHIV 2 is less easily transmitted, less pathogenic andMTCT is relatively rare.HIV attacks white blood cells, called CD4 cells thatprotect the body from illnessInfection with HIV results in a progressive destructionof the CD4 lymphocytesThe rate of CD4 cell decline, determines the rate ofIMMUNODEFICIENCY and development of HIVrelated opportunistic diseases.The destruction of the T cell is mainly due to activeviral replicationAverage time taken for development ofAIDS following infectionAverage developerdevelop AIDS within approximately 10 yearsRapid developersdevelop AIDS within 5 years following infection (20%)Slow developerswho remain asymptomatic for over 10 years withoutsignificant decline in CD4T cell count (5%).CLINICAL STAGING OF HIV INFECTION1. Primary: (seroconversion syndrome).Occurs 2-6 weeks after infectionAntibodies become detectable2. Asymptomatic HIV: (latent HIV).HIV viral replication still active (esp. In lymph nodes)immunity declines gradually.No clinical symptoms3. Symptomatic HIV:opportunistic diseases set in4. Clinical AIDS.Patient has AIDS defining illnessAcute HIV syndrome50-70% of persons affected . 2-6 weeks after pri

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