thrombosis in pregnancy

Apr 16th, 2015
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THROMBOSISPresenterDr. Esther NabakweLecturerDepartment - CHAPEpedemiology Common in newborns Uncommon in older children Incidence - 0.5;1.6/1000 persons per yearMechanisms Abnormal platelet adhesiveness &aggregation Vessel injury - trauma Activated coagulation Defective or deficient anticoagulant Dysfunctional fibrinolytic mechanism Reduced blood flowDifferential DiagnosisHereditary Deficiency of proteins C, S,plasminogen and antithrombin III Procoagulant protein uninhibitedby factor V Leiden Prothrombin mutation ( G20210A) HomocystinuriaCTAcquired Indwelling catheters, phlebitis ,sepsis Surgery, malnutrition Vascular occlusion by a platelet orfibrin plug SLE, Kawasaki disease,homocystinuria, SCD, polycythaemiaCT DIC L-asparaginaseClinical Features Symptoms acute Organ or tissue injury Distension from occlusion of venous bloodflowDiagnosisSpecific assaysDoppler U/SMRIContrast angiographyRaised D-dimers , FDPsDIC thrombocytopaenia, raised PT & PTT-hypofibrinogenaemia,C/I of AnticoagulationCoagulation defect or bleeding disorderRecent CNS haemorrhageBleeding from inaccessible siteMalignant hypertensionBacterial endocarditisRecent eye, brain or spinal cord surgeryAdministration of regional or lumber blockanaesthesiaRXNSAIDSHeat compressionRestElevation of a

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