medical notes

Apr 17th, 2015
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CRYPTOCHIDISMCryptorchidism is the most common genital problem encountered in pediatrics, refers to an un-descended or mal-descended testis.Testicular embryologyNormal testicular development begins at conception. The testis-determining factor is now identified as the SRY gene (sex-determining region on Y chromosome).The presence of this gene and an intact downstream pathway generally result in testicular formation.At 3-5 weeks' gestation, the gonadal ridge or indifferent gonad develops, and at 6 weeks, primordial germ cell migration occurs.Soon after, Sertoli cells develop and secrete mllerian-inhibiting substance (MIS), the level of which remains high throughout gestation and causes regression of mllerian ducts.At 9weeks, Leydig cells develop and secrete testosterone. Up to 28 weeks there is transabdominal movement to the internal inguinal ring. Transinguinal migration, thought

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