medical notes

Apr 17th, 2015
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CERVICAL INTRAEPITHELIAL NEOPLASIADefinition: Cervical intraepithelial neoplasia (CIN), formerly called dysplasia, means disordered growth and development of the epithelial lining of the cervix. General ConsiderationsLower genital tract squamous intraepithelial neoplasia is often multicentric (i.e. affecting multiple anatomic sites which embryologically are derived from the same anogenital epithelium): cervical intraepithelial neoplasia (CIN), vaginal intraepithelial neoplasia (VAIN), vulvar intraepithelial neoplasia (VIN), and perianal intraepithelial neoplasia (PAIN).Approximately 10% of women with CIN have concomitant preinvasive neoplasia of the vulva, vagina, or anus. Conversely, 40-60% of patients with VIN or VAIN have synchronous or metachronous CIN.ClassificationThere are various degrees of CIN. Mild dysplasia or CIN I is defined as disordered growth of the lower third of the epithelial lining. Abnormal maturation of two-thirds of the lining is called moderate dysplasia or CIN II. Severe dysplasia, CIN III, encompasses more than two-thirds of the epithelial thickness with carcinoma in situ (CIS) representing full-thickness dysmaturity While histologically evaluated lesions are characterized using the CIN nomenclature, cytologic smears are classified according to the Bethesda system The Bethesda System 20011. Specimen Type Indicate conventional smear (Pap smear) vs liquid-based vs. other 2. Specimen Adequacy Satisfactory for evaluation (de

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