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Asthma in PregnancyTimothy Hoskins, M.D.October 5, 2005ObjectivesElicit pertinent history from asthma patientPerform targeted physical exam to detect findings associated withasthmaInterpret Results of basic PFTs FEV1Describe differential diagnosis of asthmaDescribe indications for referral of a patient with more severeasthmaReview basic pathophysiology of asthmaReview treatment of asthma in antepartum, chronic, and acutestagesEpidemiology of Asthma15 million people in the U.S. have asthma2003 estimated prevalence of asthma in pregnantwomen was 5%-9%According to the National Asthma Education Programan additional 10% of the population appears to havenonspecific airway hyper responsivenessPrevalence of asthma appears to be increasing inpregnant women0.2% of pregnancies will be complicated by statusasthmaticusPathophysiology of AsthmaCharacterized by chronic airway inflammation withacute reversible airway obstruction to a variety ofstimuliObstruction component: bronchial smooth musclehyper responsiveness to stimuliInflammatory component: Divided into two separateresponsesEarly asthmatic response medicated by histamine occurswithin minutesLate asthmatic response non histamine related occurs overhoursPathophysiology of AsthmaChronic Inflammatory DisorderHallmarks reversible airway obstruction for bronchialsmooth muscle contraction, mucous hyp

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