Medicine an Surgery notes

Apr 24th, 2015
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CHOLERSTEROL AND LIPIDSAim;The overall aim of lipid-modifying treatment is to reduce the circulating levels of atherogenic lipids in order to slow, reverse or ideally prevent the development of atherosclerotic vascular lesions and thereby reducing the long term risk of cardiovascular disease.Relevant PathophysiologyCholesterol is a major component of lipid containing atherosclerotic plaques. Raising plasma levels of cholesterol and related lipid disturbances have been identified as a major risk factor (along with smoking and hypertension) for atherosclerotic cardiovascular disease and its consequences, particularly myocardial infarction.Cholesterol is derived both from the diet and by endogenous synthesis in the liver.Cholesterol;A component of all cell membranesPrecursor of steroid hormones, bile salts, glycoproteins and quiononesThe biochemistry and metabolism of cholesterol are complex.Cholesterol and other lipid fractions are transported in blood via lipoproteins of different densities.Increased total cholesterol and its major component fraction, LDL cholesterol have been linked to accelerated atherosclerosis and increased coronary artery disease.LDL cholesterol is cleared from the circulation by specific receptors on the cell surface and the function of these receptors plays an important role in determining the plasma levels of LDL cholesterol.HDL appears to have a protective and anti-atherogenic effect because it is involved in the mobilization of choleste

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