Medicine an Surgery notes

Apr 24th, 2015
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IsoimmunizationCh 162009-2010 Academic YearMSIII Ob/Gyn ClerkshipSelf-Directed Study2009-2010USUHS MSIII Ob/GynClerkship Self Directed StudiesCase Study24 yo G2P0010 at 12 weeks ega presentsfor routine antenatal visit. Blood type is Anegative. She had a spontaneousabortion with her first pregnancy 2 yearsago. She cannot remember if she everreceived Rhogam. On her initial OB labs,her antibody titer returns at 1:128.Discuss this case, including managementof Rh- women with respect to antibody titerand fetal risks.2009-2010USUHS MSIII Ob/GynClerkship Self Directed StudiesAPGO Educational Topic 19: A. Describe the pathophysiology ofisoimmunization, including: Red blood cell antigens. Clinical circumstances under which Disoimmunization is likely to occur. B. Discuss the use of immunoglobulinprophylaxis during pregnancy for the preventionof isoimmunization. C. Discuss the methods used to identifymaternal isoimmunization and the severity offetal involvement.2009-2010USUHS MSIII Ob/GynClerkship Self Directed StudiesPathophysiology Rh-negative = Absence of Rh antigen onRBCs. Many proteins make up Rh complex, but theD protein (or antigen) is most commonlyassociated with isoimmunization (90% cases) Sensitization = Rh neg person exponsedto the Rh (D) antigen and makesantibodies against that protein (antigen).2009-2010USUHS MSIII Ob/GynClerkship Self Directed StudiesHow does Mom becomeSensitized?

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