Medicine and surgery notes

Apr 24th, 2015
Studypool Tutor
Price: $10 USD

Tutor description

Word Count: 728
Showing Page: 1/21
THROMBOTIC DISORDERS Oclussion of blood vessel by platelet plug orfibrin clot may occurin vessel of any size. Capillary & small vessel: inVasculitic dsesDICMedium sized vessel: inCyanotic CHDHomocystinuriaDehydrationPolyarteitis nodosaCont.. Larger vessels: inAortic thrombosisSVC thrombosisDVTSC AnaemiaPulmonary EmbolismPATHOGENESIS Vessel injury in addition to;Abnormal platele adhessivenessaggregationAn activated coagulation mechanismAn inactive inhibitor systemAn inactive fibrinolytic mechanismReduced blood flow.Cont..a)b)c)d)Formation of clot is regulated by acomplex inhibitor system involving:Antithrombin IIIProtein CA co-factor for activated protein C(probably factor V)Protein SCont.. They prevent;a) Spontaneous intravascular coagulationb) Limit thrombotic response of body toinjury.c) Control extension of existing clotsReduced plasma levels leads to propensityto excessive thrombosisCont.. Thromboembolic dses in deficient ptspredominantly affect the venous system.-Arterial forms are rare. Manifestations:DVT of legs,pulmonary embolism,thrombosis of pelvic veins,sagittal sinus thrombosis 1 st thrombolitic event usually occurs from 1025 yrsCAUSES A) Congenital and Inherited defectsCongenital hypoplasmonogenemia anddysplasminogenemia reduced ability to remove fibrinclots Plasminogen abnormalitiesCongenital dysfibrinogenemia format

Review from student

Studypool Student
" Awesome! Exactly what I wanted. "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1820 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors