Medicine an Surgery notes

Apr 24th, 2015
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CLINICAL PHARMACOLOGYDefinition;The study of pharmacokinetics and pharmacodynamics of drugsPharmacokinetics is the description of drug concentration profile against time. Its application in clinical practice is called clinical pharmacokinetics.Pharmacodynamics is the principle of study of drug action concerning residual variability of the relationship between dose and response; a measure of sensitivity of a patient to the drug. Pharmacodynamics;This is the study of the Principles of drug actionPharmacological agents are used in therapeutics to;1) Cure disease;Chemotherapy in cancer or leukemiaAntibiotics in specific bacterial infections2) Alleviate symptoms;Antacids in dyspepsiaNon-steroidal anti-inflammatory drugs in rheumatoid arthritis3) Replace deficiencies;Thyroxine in hypothyroidismInsulin in diabetes mellitus4) prevent or delay end-stage consequences of degenerative diseases, aging, etc.A drug is a single chemical entity that may be one of the constituents of a medicine.A medicine may contain one or more active constituents (drugs) together with additives to facilitate administration.Mechanisms of drug actionAction on a receptorA receptor is a specific macromolecule, usually a protein, to which a specific group of drugs or naturally occurring substances ( such as neurotransmitters or hormones) can bind.An agonist is a substance that stimulates or activates the receptor to produce effect. e.g. salbutamol at the 2-receptor.An antagonist prev

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