Medicine an Surgery notes

Apr 24th, 2015
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Premature Ovarian FailureACOG Medical Student TeachingModule2009What is premature ovarian failure? Decline in normal functioning of theovaries in a woman younger than 40 yearsof age AKA: Primary ovarian insufficiency,hypergonadotropic hypogonadism The term premature menopause has fallenout of favorTwo Subgroups Total follicle depletion No follicles left in ovary, no ability to makemore Follicle dysfunction Some residual follicles in ovary, but they arenot working properlyPrevalence 1/250 by age 35 1/100 by age 40Symptoms of Premature OvarianFailure Most common first symptoms: irregularperiods, Infertility Symptoms similar to menopause Hot flashes, night sweats Irritability, poor concentration Decreased libido Vaginal drynessAssociated health conditionsOsteoporosisHypothyroidismAddison's diseaseDiabetesHeart diseaseFragile X carriers more likely to developpremature ovarian failureTestingElevated FSH prior to age 40 is diagnosticEstridiol (low)LH (low)KaryotypeDont forget pregnancy test!Causes Unknown ? Genetic: 10-20 percent of women withPOF have a family history ? Autoimmune: association with thyroiddysfunction and diabetes MUST SCREEN FOR THESE CO-MORBIDITIES! Chemotherapy, Radiation, CigaretteSmoke, Chemicals, PesticidesTreatment No proven treatment to restore ovarianfunction HRT f

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