Medicine an Surgery notes

Apr 24th, 2015
Studypool Tutor
Price: $60 USD

Tutor description

Word Count: 721
Showing Page: 1/8
UTERINE FIBROIDSPresentationPathophysiologySigns and symptomsDiagnosisManagementPrognosisPathophysiologyPathogenesislarge subserosal fibroidMonoclonal tumors Approximately 40 to 50% show karyotypically detectable chromosomal abnormalitiesWhen multiple frequently have unrelated genetic defectsSpecific mutations of the MED 12 protein have been noted in 70 percent of fibroidsExact aetiology is not clearly understoodCurrent working hypothesis: genetic predispositions, prenatal hormone exposure and the effects of hormones, growth factors and xenoestrogens cause fibroid growth. Known risk factors nulliparity obesity polycystic ovary syndrome diabetes hypertension - atherosclerotic inflammatory injury to uterine vesselsGenetic - First degree relatives have a 2.5-fold risk, and nearly 6-fold risk when considering early onset casesOestrogen and progesterone:Have a mitogenic effect on leiomyoma cells Influence (directly and indirectly) a large number of growth factors, cytokines and apoptotic factors as well as other hormones. Actions modulated by with prolactin signalling which controls the expression of respective nuclear receptorsGrossly - round, solid, white or tan,well circumscribed (not encapsulated) nodules Histological section - whorled appearance Location and classificationSchematic drawing of various types of uterine fibroids: a=subserosal fibroids (can pedunculate) b=intramural fibroids, c=submucosal fibroid d=pedunculated submu

Review from student

Studypool Student
" Thank you, Thank you, for top quality work, this is your guy!! "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1830 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors