Medicine an Surgery notes

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Tumour Markers In GynecologyProf.Surendra Nath Panda, M.S.&Dr.Arati Nayak, M.B.B.S.Department of of Obstetrics & GynecologyM.K.C.G.Medical CollegeBerhampur, 760004, Orissa, IndiaTumour Markers: Definition: A tumour marker is a biochemical indicatorselectively produced by the neoplastic tissue andreleased into blood and detected in blood or inother body fluids. It may be used to: Detect the presence of a tumour Monitor the progress of disease Monitor the response to treatment They cannot be constructed as primarymodalities for diagnosis of tumoursTumour Markers: Types of Tumour markersCell surface antigens.Cytoplasmic proteins.Enzymes.Hormone. Criteria of an Ideal Tumour Marker: Specific Sensitive The method of assay must be cheap & easyTumour Markers: - Classification Class 1: Antigens unique to a neoplasm not shared byother tumours of same histological type . Class 2: Antigens expressed by many or most tumours ofa specific histological type and of otherhistological type, But not expressed by normal adult tissue. Class 3: Antigens expressed by both cancer and normaladult tissue.Tumour Antigens : With Malignant Transformation Of A BenignTumour Some Modifications may Occur InThe Tumour Antigens. Expression of new tumour antigen. Increase / decrease in expression of presenttumour antigen. Micro anatomic changes in distribution of cell

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