Medicine an Surgery notes

Apr 24th, 2015
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Module 3: Management ofPatients on Antiretroviral TherapyUnit 1: Antiretroviral DrugsObjectivesAt the end of the session participantsshould: Describe the classification of ARVs Explain the sites and modes of action ofARVs Describe available ARV drug formulationsand adult dosesHIV Life Cycle: ReviewAttachment toCD4 receptorsite (and coreceptor)Mature virusProteaseNew virionsbudding fromcellManufactureand assemblyof new viralproteinsFusionReverseTranscriptaseCapsidreleased intolymphocyteTranscription usingRT to create dsDNAcopyIntegraseNewviral RNAIntegration ofviral DNA intohuman genomeAntiretroviral Drugs: ClassificationAt present 2 main classes available locally Reverse Transcriptase Inhibitors (RTIs)1. Nucleoside and Nucleotide RTIs (NRTIs and NtRTI)2. Non-nucleoside RTIs (NNRTIs)Protease Inhibitors (PI)Other Classes: New AntiretroviralDrugsA supply of new antiretroviral drugs is still necessarybecause of the limitations of current ARVsToxicityDrug resistanceDosing schedule, pill burdenTo be useful new drugs shouldPreferably have new site of activity thus reducing likelihood ofresistanceHave increased activity against recognized resistant strainsBe well toleratedHave a convenient dosage scheduleBe synergistic with existing drugsNew Antiretroviral DrugsEntry and Fusion InhibitorsInvestigational and approved drugs.Interfere

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