Medicine an Surgery notes

Apr 24th, 2015
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RHABDOMYOSARCOMAIntroductionRhabdomyosarcoma is the most common soft-tissue tumor in children, accounting for approximately 5% of all pediatric cancers.Age-The tumor presents throughout childhood and has even been reported at birth. -The peak incidence is between 2 and 5 years of age, with 70% of children diagnosed before 10 years of age. -A second smaller peak is seen in adolescents with extremity tumors.Sex Males are affected more commonly than females (1.4:1).RaceWhites x3 more affectedAetiologyUnknown- Associated with Fraumeni syndrome is an inherited mutation of the p53 tumor suppressor gene that results in a high risk of bone and soft tissue sarcomas in childhood plus breast cancer and other malignant neoplasms before age 45. But characteristic chromosomal changes have been reported, including t(2;13) translocation and loss of allelic heterozygosity on chromosome 11.

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