Medicine an Surgery notes

Apr 25th, 2015
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TARGETED THERAPY Targeted therapy is a type of medication that blocks the growth of cancer cells byinterfering with specific targeted molecules needed for carcinogenesis and tumorgrowth rather than by simply interfering with rapidly dividing cells (e.g. withtraditional chemotherapy). Targeted cancer therapies may be more effective than current treatments and lessharmful to normal cells. The definitive experiments that showed that targeted therapy would reverse themalignant phenotype of tumor cells involved treating Her2/neu transformed cells withmonoclonal antibodies in vitro and in vivo by Mark Greenes laboratory. The main categories of targeted therapy are;1) Small molecules2) Monoclonal antibodies.Mechanism of imatinibSmall molecules These include;1) Imatinib mesylate (Gleevec)2) Gefitinib (Iressa)3) Erlotinib (Tarceva)4) Bortezomib (Velcade)5) Tamoxifen (selective estrogen receptor modulator)6) Other newer agents; Bcl-2 inhibitors (e.g. obatoclax in clinical trials, ABT-263, andGossypol. PARP inhibitors (e.g. Iniparib, Olaparib in clinical trials) Apatinib is a selective VEGF Receptor 2 inhibitor Imatinib mesylate (Gleevec, also known as STI571) is approved for chronicmyelogenous leukemia, gastrointestinal stromal tumor and some other types ofcancer. Early clinical trials indicate that imatinib may be effective in treatment ofdermatofibrosarcoma protuberans. Gefitinib (Iressa, also known as ZD1839

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