Medicine an Surgery notes

Apr 25th, 2015
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CLINICAL PHARMACOLOGYDefinition;The study of pharmacokinetics and pharmacodynamics of drugsPharmacokinetics is the description of drug concentration profileagainst time. Its application in clinical practice is called clinicalpharmacokinetics.Pharmacodynamics is the principle of study of drug action concerningresidual variability of the relationship between dose and response; ameasure of sensitivity of a patient to the drug.Pharmacodynamics;This is the study of the Principles of drug action.Pharmacological agents are used in therapeutics to;1)Cure disease;Chemotherapy in cancer or leukemiaAntibiotics in specific bacterial infections2)Alleviate symptoms;Antacids in dyspepsiaNon-steroidal anti-inflammatory drugs in rheumatoid arthritisReplace deficiencies;1)Thyroxine in hypothyroidism2)Insulin in diabetes mellitusprevent or delay end-stage consequences of degenerative diseases, aging,etc.A drug is a single chemical entity that may be one of the constituents of amedicine.A medicine may contain one or more active constituents (drugs) together withadditives to facilitate administration.Mechanisms of drug actionAction on a receptorA receptor is a specific macromolecule, usually a protein, to which a specificgroup of drugs or naturally occurring substances ( such as neurotransmitters orhormones) can bind.An agonist is a substance that stimulates or activates the receptor to produceeffect. e.g. salbutamol at the

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