Medicine an Surgery notes

Apr 25th, 2015
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MembersDrugMechanismadalimumabTNF inhibitorazathioprinePurine synthesis inhibitorchloroquine and hydroxychloroquine (antimalarials)suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factorsciclosporin (Cyclosporin A)inhibit calcineurinD-penicillamineReducing numbers of T-lymphocytes etc.etanerceptTNF inhibitorgolimumabTNF inhibitorgold salts (sodium aurothiomalate, auranofin)inhibits macrophage activationinfliximabTNF inhibitorleflunomidePyrimidine synthesis inhibitormethotrexate (MTX)Antifolateminocycline5-LO inhibitorrituximabchimeric monoclonal antibody against CD20 on B-cell surfacesulfasalazine (SSZ)suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factorsAlthough these agents operate by different mechanisms, many of them can have similar impact upon the course of a condition.[4]Some of the drugs can be used in combinationChloroquine and HydroxychloroquineThese drugs originally developed as antimalarials have been used to treat RA and SLE since 1950's and responses in RA are similar buut somewhat less than those observed with other DMARDs except for auronofin(oral gold). However the major advantage in their lack of life threatening toxicity compared to other DMARDS and are increasingly being used early in the course of the disease and in combination regimens with other DMARDs. The mechanism of action of these preparations may be by suppression of

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