Medicine an Surgery notes

Apr 25th, 2015
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CHICKEN POXkibaruIntroductionChickenpox is an acute viral infectious disease acutefebrile rash illnessIt has variable severityis usually self-limitedIt may be associated with severe complications,includingbacterial superinfection pneumonia Encephalitis bleeding disorders congenital infection life-threatening perinatal infectionAlthough often a mild illness of childhood,chickenpox can cause substantial morbidity andmortality in otherwise healthy childrenit causes increased morbidity and mortality inAdolescents adults immunocompromised personsIt predisposes to severe group A streptococcusand Staphylococcus aureus infections.ETIOLOGY.VZV is a neurotropic human herpesvirusThese viruses are enveloped double-stranded DNA genomesVaricella-zoster virus (VZV) causesPrimaryLatentrecurrent infections.The primary infection is manifested as varicella(chickenpox)It results in establishment of a lifelong latentinfection of sensory ganglion neurons. Reactivation of the latent infection causes herpeszoster (shingles).EPIDEMIOLOGY.Varicella communicable infection of childhoodMost children infected by 15 yr of age with fewer than 5% of adults remaining susceptibleVaricella is a more serious disease with higher ratesof complications and deaths amonginfants adults immunocompromised persons.herpes zoster in children tends to be mil

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