Medicine an Surgery notes

Apr 25th, 2015
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kibaruHSV are 2 closely related viruses; type 1 & 2 Cause a variety of illness depending on anatomic site of initial infection host immunity primary or recurrentCommon sites eyes, skin, oral, genital Causes Less common severe infection inneonates and immune compromisedindividuals. Primary infection- patient without preexisting antibodies to HSV1 or HSV2( can besevere)Non primary 1st episode infectionacquisition of HSV1 in patient with preexisting antibodies to HSV2 & vice versa(less severe due to cross-protection)Recurrent infection- reactivation of HSV inwhich the HSV type recovered in the lesionis the same type as the Abs in the serum(HSV ascends peripheral sensory nervesand enters sensory, autonomic nerve rootganglia where latency is established)Ubiquitous infection with no seasonalvariation. Humans only natural host. Transmission is by direct contact of mucocutaneous surfacesAll infected individuals harbour latentinfection which may recur eithersymptomatically or asymptomatically but all recurrences are contagiousHSV-1 & 2 cause initial infection at any sitebut recurrent infection: HSV-1 haspropensity for oral and HSV-2 genital Higher prevalence of infection in femalesthan males.Other risk factors include;povertyless educationcocaine usehigher numbers of sexual partnersPrior HSV-1 infection seen to afford someprotection agains

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