Medicine an Surgery notes

Apr 25th, 2015
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MMRKIBARUINTRODUCTIONThe measles virus causes an acute infectioncharacterized by fever, cough, coryza, conjunctivitis, rash,and enanthem that may be followed by severecomplications, including encephalitis. The mumps virus causes an acute self-limited viralsyndrome, which occurred principally in school-childrenbefore the widespread use of mumps vaccine.Rubella virus causes German measles, a generallymild infection with a characteristic rash that can affectboth children and adults rubella infection can cause significant birth defects if it occurs early in fetal life.Measles : The VaccineAll measles vaccines are live-attenuatedCharacterized by the strain (Schwartz;Moraten; Edmonston-Zagreb)Standard titre vaccines contain about butnot less than 3 log10 (1000) infectious unitsper dose (WHO)Administered subcutaneouslyPrevention of measles Response to vaccinationVaccinationlong-term protectionseroconversion to vaccine: 85%at 9 months 93% at 12 months 95% at 15 monthsafter the second dose : 99% seroconversionWHO: 1 dose measles vaccine policy isinsufficient to achieve and sustain correctmeasles control target as it leaves animportant proportion of children susceptibleVaccination scheduleRecommended age of vaccination (1stdose)developing countriesillness at an earlier ageVaccination at 9 monthsdeveloped countries vaccination afte

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