Medicine an Surgery notes

Apr 25th, 2015
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ABO and RhISOIMMUNISATIONProfessor. Surendra Nath Panda, M.SDept. of Obstetrics & GynaecologyM.K.C.G.Medical CollegeBerhampur-760004, Orissa, IndiaThe Basics Of BloodW.B.C. & PlateletR.B.C.PlasmaANTIGENANTIBODY>400 Agglutinogens on the cellmembraneNatural & ImmuneAgglutinins/IsoantibodiesAntigen-Antobody reaction on thecell surface HemolysisThe Basics Of BloodAntigens: - Controlled by genes at unknown No. ofchromosomal loci. Appearance by 40 days of I.U. Life- unchanged tilldeath. Also present in tissues & tissue fluids. Blood group system: A group of antigens controlledby a locus having a variable no of allele genes.The Basics Of BloodAntigens: - > 15 blood group systems are recognised : ABO,Rh, Kell, Duffy, MN, P, Lewis, Lutheran, Xg,Li, Yt, Dombrock, Colton, Public antigens & Privateantigens. Blood type- means individual antigen phenotypewhich is the serological expression of the inheritedgenes Most of these blood group antigens have beenfound to be associated with hemolytic disease. However ABO & Rh account for 98%The Basics Of BloodAntibodies: -Alloantibodies / AgglutininsNaturalIgMIso / immune antobodiesIgGFormed in response toforeign R.B.C. or solubleblood group substance.The Basics Of BloodNatural Antibodies: - Antibodies are formed against most of the major groupantigens & present in almost all individuals when theantigen is absent. In most oth

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