Medicine an Surgery notes

Apr 25th, 2015
Studypool Tutor
Price: $10 USD

Tutor description

Word Count: 3620
Showing Page: 1/21
Rh ISOIMMUNIZATIONDefinition: Maternal alloimmunization, also known as isoimmunization, occurs when a woman's immune system is sensitized to foreign erythrocyte surface antigens, stimulating the production of immunoglobulin G (IgG) antibodiesGeneral ConsiderationsThe D antigen is a common, strongly immunogenic antigen, 50 times more immunogenic than the other Rh antigens. The prevalence of antibody formation to Rh+ blood depends on the dose of Rh+ cells: 1 mL of cells sensitizes 15% of individuals exposed; 250 mL sensitizes 60-70%.After the initial exposure to Rh+ cells, weak IgM antibody can be detected as early as 4 weeks. This is followed by a rapid conversion to IgG antibody. A second exposure to as little as 0.03 mL of Rh+ erythrocytes may result in the rapid formation of IgG antibodiesA fetus receives half of its genetic components from its mother and half from its father and may therefore have different blood groups than those of its mother. Some blood groups may act as antigens in individuals not possessing those blood groups. The antigens reside on red blood cells. If enough fetal cells leak into the maternal blood, a maternal antibody response may be provoked. Some blood types specifically produce antibodies capable of crossing the placenta. They then enter the fetal circulation and destroy the fetal erythrocytes, causing hemolytic anemia.This leads to responses in the fetus to meet the challenge of enhanced blood cell breakdown. These changes

Review from student

Studypool Student
" awesome work thanks "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1829 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors