Medicine an Surgery notes

Apr 25th, 2015
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UTERINE FIBROIDS Definition:Uterine leiomyomas (i.e. fibroids or myomas) are benign clonal tumors arising from the smooth muscle cells of the uterus and containing an increased amount of extracellular matrix proteins (collagen and elastin).Uterine leiomyomas are well circumscribed, pseudo-encapsulated benign tumors composed mainly of smooth muscle but with varying amounts of fibrous connective tissueUterine leiomyomas originate from, and are tumors of, the smooth muscle cells of the myometrium; there is commonly an intermingling with fibrous tissue EpidemiologyUterine leiomyomas are benign neoplasms composed primarily of smooth muscle. Leiomyomas are present in 20-25% of reproductive-age women, but for an unknown reason, leiomyomas are 3-9 times more frequent in black than in white women. Uterine fibroids are the most common pelvic neoplasm, occurring in 1/4 of white and 1/2 of black womenLeiomyomas are extremely common, being found in at least 20% of women above the age of 35; they are usually multiple and vary in size from tiny 'seedlings' to huge masses which fill the abdomen.Indeed, by the fifth decade as many as 50% of black women will have leiomyomataPredominant age: Most women with symptomatic fibroids are in their 30s or 40s. Leiomyomas are not detectable before puberty and, being hormonally responsive, normally grow only during the reproductive years. Relief of symptoms related to fibroids usually occurs at the time of menopause, when menstrual cycli

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