Medicine an Surgery notes

Apr 25th, 2015
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Cervical carcinomaDr OgindoCancer cervixEpidemiology: The incidence of invasive cervical cancerdecreased in the west. Incidence stillhigh in 3rd world. Peak incidence 40-45 years Moreincidenceinblack(lowsocioeconomic) and Low in Jewish. The most common female cancer in thedeveloping countries where it is theleading cause of cancer death in women.80%-90% of cases are seen at lateincurable stages.Cancer cervixRisk factors: related to HPV infection1- Sexual behavior:- Early initiation of sexual intercourse- Multiple sexual partners- History of genital HPV infection or other STD e.g herpes and HIV2- Smoking3- Low socioeconomic conditions 4- Poor nutritional statusEtiology:Human Papiloma virus is a very common sexually transmitted infectionand is proven as an etiologic factor for cervical cancerRelation of HPV to cervical carcinogenesis:Cervical anatomy or biologypredisposing to squamous:carcinogenesisComposed of columnar epithelium whichlines the endocervicalcanal andsquamous epithelium that cover theectocervix .The point at which they meetis called the squamocolumnar junction(Sq.C.J).In the prepubertal female, islocated on the ectocervix and is sharp.This junction changes in response topuberty, pregnancy, menopause andhormonal stimulation. At the time ofmenarche and especially with pregnancy,physiologic eversion of the ectocervixwith the columnar epithelium and glandsexposed to the acid vaginal environm

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