MBchB study guide

Apr 25th, 2015
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AMENNORHEASALWA NEYAZICOSULTANT OBSTETRICIANGYNECOLOGISTPEDIATRIC & ADOLESCENTGYNECOLOGISTAMENORRHEAWHAT IS 1RY AMENORRHEA?Lack of the onset of menses by the 16 Y in a with 2ry sexual chct or by the age of 14 Y in without 2ry sexual developmentWHAT IS 2RY AMENORRHEA?Cessation of menses for a period of 6monthsin a who previously had initiation of mensesCLASSIFICATION OF1RY AMENORRHEAA-BREAST ABSENT UTERUS PRESENTGONADAL DYSGENESIS1-TURNER SYNDROME 45XOVariations of Turner s syndrome 2-Mosaicism XO/XX not always shortThey will have menses , get pregnant then develop premature menopause3-Structural abnormalities of the X chromosomeDeletion of the short arm of the Xchromosome Short stature Deletion of the long arm normal HT, 2ryAmen, streak gonadsTURNER SYNDROMEFEATURES1ry amenorrheaNo breast developmentNormal genital organs (external /internal)Streak gonads (ovaries are replaced by whitenonfunctioning tissue)Short statureWebbed neck (Short broad neck) with a low hairlineCubitus vulgusShield chest / Widely spaced nipplesHigh arched palateShort 4th metacarpalCoarctation of the aorta or VSDHorse shoe kidney or single kidneyGONADAL DYSGENESIS4-Pure gonadal dysgenesis 46XXMutation in an autosomal gene Accelerated germ cell loss Streakgonads genetalia , normal Mullerian structuresRarely Turners Stigmata5- Pure gonadal dysgenesis 46 XY genitaliaStreak gonads risk

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