MBchB study guide

Apr 28th, 2015
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MALIGNANT VULVAR LESIONSEpidemiologyIncreasingly data suggest that human papillomavirus (HPV) may be a cause of some vulvar malignanciesVulvar cancer accounts for approximately 5% of all female genital malignanciesWith the exception of the rare sarcomas, this cancer appears most frequently in women aged 65-75 years, and, in some series, almost half of the patients are aged 70 years or older.DiagnosisHistological evaluation is a prerequisite before planning definitive therapy for changes in the epithelium of the vulva, whether pigmentation, hypertrophy, or lump or mass occursMost vulvar cancer is squamous in origin. Because the vulva is covered with skin, any malignancy that appears elsewhere on the skin also can occur on the vulva. Melanoma is the second most frequent histological type, but this represents less than 5% of vulvar cancersSquamous vulvar cancer can have many different growth characteristics. It can occur in an area of epithelial neoplasia that develops into a small nodule, which may break down and ulcerate. Small, warty, or cauliflowerlike growths may arise and be confused with condyloma acuminata. Squamous carcinomas can appear in a background of atro

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