Obstetrics and gynaecology

Jun 13th, 2016
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Charles R Drew University of Medicine and Science
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The best notes of anemia in pregnancy

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ANAEMIA IN PREGNANCYHb 10g or haematocit 30%Causes: Haemodilution Increase plasma vol. By 40-50% & red blood cell mass by 18-25% Nutritional commonest result from deficiency of iron, folic acid or Vitamin B12 Aplastic Drug induced.1. IRON DEFICIENCYResponsible for about 95% of anaemias during pregnancy.Total body iron compriseso Iron in haemoglobin (about 70% of total iron)o Iron stored as ferritin & haemosiderin in Reticulo-endothelial system (R.E.S) in bonemarrow, spleen and parenchyma cells of the liver (about 300g)o Haemosiderin contains 37% more iron than does ferritin.o Small amounts in myoglobin, plasma and various enzymes.Order of depletion:o Absence of haemosiderin in bone marrow (diagnostic of anaemia - one of earliestsigns of iron deficiency)o Decrease of serum iron & an increase in serum total iron binding capacity & anaemia.o Total needs in normal pregnancy = 8000mg (500mg due to maternal red blood cellmass & 300mg foetus)- From diet 10-15mg/dl hence supplementation crucial.- Treatment oral or parental (e.g. inferron 1m or IV).Clinical findings:S/S Symptoms may be vague & non-specific including p

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