Muscular blocking agents

Jun 27th, 2016
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The document contains a well elaborated classification and indications for neuro muscular blocking drugs.

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1NEUROMUSCULARBLOCKING DRUGSWhy?2Improve conditions for tracheal intubationProvide immobility during surgeryFacilitate mechanical ventilationWhere?3Nicotinic cholinergic end plate of the muscle.Ideal properties4Non-depolarizing actionRapid onset (within one circulation time)Short duration, suitable for infusionRapid metabolism to inactive productsAntagonized by cholinesterase inhibitorsActions confined to the NMJNot transferred across the placenta or blood-brain barrierNo local or systemic side-effectsCompatibility with other drugs and solutionsLong shelf life without refrigerationCheapGroups/Classifications5Depolarising-Produces depolarization at theendplate.Non-depolarising-Compete with acetylcholine forthe same binding sites.Contd6Short actingSuccinylcholineMivacuriumIntermediate actingAtracuriumCisatracuriumRocuroniumVecuroniumContd7Long actingAlcuroniumDoxacuriumD-TubocurarineGallamineMetocurinePancuroniumpipercuroniumContd8SuccinylcholineBenzylisoquinolonesD-TubocurarineAtracuriumMivacuriumDoxacuriumCisatracuriumContd9AminosteroidsPancuroniumVecuroniumPipercuroniumRocuroniumRapacuroniumSuccinylcholine10Fast onset of action-within 30 secondsShort duration of acti

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