Research on the Effect of Vismodegib on the rate of erythrocytes programmed cell death over time.

Jul 12th, 2016
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Investigate the effects of vismodegib on the rate of erythrocytes programmed cell death over time, ( span of 48hrs incubation) We aim to use different concentrations of the drug to see which works best. ( optimum concentration) The hypothesis is that as the concentration of drug increases, cell death will also increase. Concentration ( independent variable) Eryptosis (dependent Variable)

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Research on the Effect of Vismodegib on the rate of erythrocytes programmedcell death over time.PROJECT PROPOSAL TEMPLATEWord count 1654NAMEPROPOSED PROJECT TITLEEryptosisNAME OF SUPERVISORComplete with YES or NO asappropriateConfirm online ethics forms submitted see separate instructions for submission.YESIncludes all attachments and riskassessment form.Project file started, meetings formsYEScompleted and reflective diary on going.Laboratory based projectsMet with relevant technician? EquipmentYESand consumable requisition formcompleted and submitted to relevanttechnician?Is training for blood/saliva collectionYESrequired?Has this been completed?NO, will be attending the session onIf not, and applicable, you will need toNovember**attend before data collection can begin.LITERATURE REVIEWThis term is the disorder that embroils the impulsive death of theerythrocytes characterized by the shrinking of the cell, the blebbing of themembrane, activation of protease, and phosphatidylserine exposure at theouter membrane. This condition is activated by injury to the erythrocytecells that happens due to several stressors, which includes the oxidativestress. Eryptosis from its paraphernalia to other biological functionsdevelops a mechanism that makes the erythrocytes discharge haemolysis.On dissimilar situation, increased eryptosis disorder favours the progress ofanaemia. Some illnesses that are related to moderate condition of

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