Comparative study between clomiphene and Letrozole for ovulation induction in patients with polycyst

Feb 3rd, 2012
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Topic: Gynae and Obst: Comparative study between clomiphene and Levatazole for ovulation induction in patients with polycystic ovarian syndrome Attached herewith is the format of synopsis and assessment criteria. Study is setting is for Pakistan. Also attached herewith is the sample synopsis for writer's understanding. Polycystic ovary syndrome is a heterogeneous endocrine dysfunction that affects about ¼ of women worldwide. This is majorly due to excessive androgen secretion or activity in the body and an enormous number of women may also have abnormal insulin activity. Various systems of the body get disturbed due to polycystic ovarian syndrome resulting in several complications including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes i.e.; non-insulin dependent and a still debated increased risk of cardiovascular disorder.

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INTRODUCTIONPolycystic ovary syndrome is a heterogeneous endocrine dysfunction that affects about of women worldwide. This is majorly due to excessive androgen secretion or activity in the body and an enormous number of women may also have abnormal insulin activity. Various systems of the body get disturbed due to polycystic ovarian syndrome resulting in several complications including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes i.e.; non-insulin dependent and a still debated increased risk of cardiovascular disorder.Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio.Generally there was no significant difference seen in responders and non-responders of letrozole in age, period of infertility, body mass index, and LH, FSH, or LH/FSH ratio.This syndrome is common in women of reproductive age. Infrequent or prolonged menstrual periods, excess hair growth, acne and obesity can all occur at once or individually in women with polycystic ovary syndrome. Infrequent or absent menstruation may indicate the presence of this condition. In women, weight gain and difficulty in conceiving is the first sign of this syndrome.Clomiphene is a standard drug f

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