Feb 3rd, 2012
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University College London (UCL)
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Biotin, a water-soluble vitamin, is used as an essential coenzyme for five carboxylases in mammals; propionyl-CoA carboxylase; methylcrotonyl-CoA carboxylase; pyruvate carboxylase, and two isoforms of acetyl-CoA carboxylase. Each of these biotin-dependent carboxylases catalyzes an essential step in pathways involved in gluconeogenesis, fatty acid metabolism, and amino acid catabolism; thus, biotin plays an essential role in maintaining metabolic homeostasis. this essay describe extensively the structure of biotin and its role in human cell function.

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