The Ageing Cell : Mitochondria & Waste Disposal

May 20th, 2015
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There are many stress detectors in the cell to ensure that homeostasis is maintained. If response/repair pathways fail ageing and cancer can be the result. There are mechanisms that detect misfolded proteins and damaged biomolecules

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SCRA.18 AB.01 AGEING BIOLOGY 01 Introduction to the Biology of Ageing The Ageing Biology focuses on the ageing process and ageing-related diseases. Principles from the Stem Cell Biology and Regeneration Lectures will be used. It is important to understand the effects of ageing on different levels: the molecular, cellular, tissue and organ. Key objectives - Appreciate the costs of our ageing population and the need for research if we are to enable healthy ageing- Describe the characteristics and a possible definition of ageing - Know that there are several segmental progeroid syndromes that could give us clues as to human ageing- Describe the advantages of invertebrate model organisms and what they have told us about possible mechanisms of ageing including SIRTs, TOR and IGF signalling (more in later Lectures)The worldwide populating is ageing and people are living longer. It has been predicted that by 2025 1.2 billion people will be over 60 years old and many more people will be over 80 and above. This will mean that more people will be living with multiple chronic conditions. Defining Ageing There are many changes that occur as an organism ages: accumulation of nuclear and mitochondrial DNA damage due to oxidative stress, gradual immunodeficiency leading to decreased immunity to infections, organs lose their ability to maintain homeostasis because signalling pathways are damaged and stochastic accumulation of tissue damage. PROGEROID SYNDROMESProge

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