Chemistry- Scopolamine

Feb 3rd, 2012
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Yale University
Course: chemistry
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Scopolamine is an anticholinergic drug believed to have a neurochemical profile different from the benzodiazepines. A recent double-blind study designed to examine the memory-impairing effects of scopolamine showed that it "produced dose-related reductions in both true and false recognition rates, and induced a more conservative response bias relative to placebo for recollection-based 'remember' responses to studied words" (Mintzer, Griffiths 2001).

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Subject- ChemistryTopic- Chemistry- ScopolamineUniversity name- Yale UniversityScopolamineScopolamine is in a family of anticholinergic hallucinogens alongwith hyocyamine, and atropine. Although they can be synthesized in alaboratory from various precursors, they are found naturally occurringin four genuses of the Solanaceae (potato) family: Atropa, Datura,Mandragora, and Hyoscyamus. People around the world have utilized theeffects of Scopolamine in manifold ways. Using extracts from AtropaBelladonna which means beautiful woman,ancient Egyptianand Romanwomen are supposed to have put the juice on their eyes leading tolarger pupils which was considered more beautiful. In more recenttimes, the prolonged dilation of the pupils known as mydriosis, hasbeen effectively employed during opthamallogical procedures. Hamlet'sfather in Shakespear's play was killed by "hebone" which is nowunderstood to have been Henbane, a Scopolamine containing plant in thegenus hyoscyamus. The witches ofmedieval timesare thought to haveused ointments made of Atropa and rubbed on a broomstick to inducefeelings of flight and visions of travels to the Witches Sabbath.Plants from the datura family were used by bands of thieves in India todrug their victims into a stupor. It has also more recently come tolight that datura is a key ingredient in a paste used in Haiti tomaintain a lack of free will in people who had been resurrected fromtheir graves a

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