Chemistry of Psilocybin and Synaptic Transmitters Involved

Feb 3rd, 2012
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Cornell University
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It has been found that some serotonergic autoreceptors are located on the serotonin containing neurons in the dorsal raphe nucleus, to be more specific the autoreceptors are found at the presynaptic nerve endings (Moret 1985). The cell bodies of these autoreceptor serotonergic neurons are located in the raphe nuclei and project into various brain regions such as the cortex, hippocampus, hypothalamus and the corpus striatum (Moret 1985). These serotonergic autoreceptors remain completely available to agonists that are added into surrounding fluid. This is because endogenous transmitters do not appear to reach concentrations high enough to activate the receptors (Moret 1985).

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