Obesity and the Risk for Gastroesophageal Reflux Disease and Its Complications

Jun 17th, 2015
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: MEDLINE search between 1966 and October 2004 for published full studies.

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Meta-Analysis: Obesity and the Risk forGastroesophageal Reflux Disease andIts ComplicationsHoward Hampel, MD, PhD;Neena S. Abraham, MD, MSc(Epi); andHashem B. El-Serag, MD, MPHFrom the Michael E. DeBakey Veterans Affairs Medical Center, Baylor College ofMedicine, Houston, Texas.AbstractBackground: The association of body mass index and gastroesophageal reflux disease(GERD), including its complications (esophagitis, Barrett esophagus, and esophagealadenocarcinoma), is unclear.Purpose: To conduct a systematic review and meta-analysis to estimate the magnitudeand determinants of an association between obesity and GERD symptoms, erosiveesophagitis, Barrett esophagus, and adenocarcinoma of the esophagus and of thegastric cardia.Data Sources: MEDLINE search between 1966 and October 2004 for published fullstudies.Study Selection: Studies that provided risk estimates and met criteria on definingexposure and reporting outcomes and sample size.Data Extraction: Two investigators independently performed standardized search anddata abstraction. Unadjusted and adjusted odds ratios for individual outcomes wereobtained or calculated for each study and were pooled by using a random-effectsmodel.Data Synthesis: Nine studies examined the association of body mass index (BMI)with GERD symptoms. Six of these studies found statistically significant associations.Six of 7 studies found significant associations of BMI with erosive esophagitis, 6 of 7found significant associ

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