CASE STUDY Class/Group: MSN104

Jun 21st, 2015
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Alabama State University
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T1 N0 M0 infiltrating ductal breast cancer on her right side based on a lumpectomy and axillary lymph node dissection over a year ago. After her radiation theraphy (daily treatment for 6 weeks) was completed, she was placed on tamoxifen( to be taken for five years). She has been coming to the clinic every 3 months for her checkup in the year since her treatment was completed. In addition to working at the clinic, you are a volunteer consultant to the encore- YWCA support group for women who have had breast cancer, where B.B. regularly attends. The group has invited you to present “breast cancer: prevention, screening, and detection guidelines” at their next meeting. 1. What is tamoxifen? Why are women placed on long- termed tamoxifen therapy as a treatment for breast cancer? Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as anagonist, and thus may be characterized as a

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CASE STUDY 1Scenario B.B., a 53 years old divorced professional woman, was diagnosed with stage T1 N0 M0 infiltrating ductal breast cancer on her right side based on a lumpectomy and axillary lymph node dissection over a year ago. After her radiation theraphy (daily treatment for 6 weeks) was completed, she was placed on tamoxifen( to be taken for five years). She has been coming to the clinic every 3 months for her checkup in the year since her treatment was completed. In addition to working at the clinic, you are a volunteer consultant to the encore- YWCA support group for women who have had breast cancer, where B.B. regularly attends. The group has invited you to present breast cancer: prevention, screening, and detection guidelines at their next meeting.1. What is tamoxifen? Why are women placed on long- termed tamoxifen therapy as a treatment for breast cancer?Tamoxifenis anantagonistof theestrogen receptorinbreast tissuevia its active metabolite, hydroxytamoxifen. In other tissues such as theendometrium, it behaves as anagonist, and thus may be characterized as a mixed agonist/antagonist. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of thiscompetitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key fro

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