The Tragedy of Hamlet

Jun 22nd, 2015
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Allen County Community College
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The Tragedy of Hamlet, Prince of Denmark is a tragedy by William Shakespeare. Set in the Kingdom of Denmark, the play dramatizes the revenge Prince Hamlet exacts on his uncle Claudius for murdering King Hamlet, Claudius's brother and Prince Hamlet's father,

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Case Report - Pigmented Villonodular Synovitis Great ToeIntroduction:-Synovitis of small joints is known. There are different varieties of joint swelling due to arthritis, synovitis is one of themhave been documented. Pigmented villo-nodular variety of synovitis (PVNS) is known to involve usually big joints likesuch as knee, but involvement of proximal meta tarso phalangeal joint of the great toe has been rarely documented.The synovium of a joint, bursae or tendon sheath may react to injury in a peculiar manner. The villous process and nodules are produced histiocytes that may contain varying amount of haemosiderin & and Llipids accumulate beneath the synovium &and fibrosis develops to variable extent.In PVNS, synovium is distinctly brownish orange &and thrown into many villous processes. Thus, recurrent episodes of painful blood effusions of joints is common in the history. X- ray may show erosion of bones by the synovial reaction, but usually its not the caseare negative.Giant cell tumour of tendon sheath may resemble PVNS but microscopically found to have less haemosiderin and& lipids. Microscopically, PVNS lesions have villi covered with synovial cells and contain an infiltrate chiefly of histiocytes and other inflammatory cells. Histiocytes contains haemosiderin &and lipids &and may fuse to form giant cells. The lesion may be cellular enough to resemble a sarcoma. Occasionally, it may protrude in to surrounding tissues and look grossly like a tumour.Cas

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